Extending Reverse Engineering to Biology
In our research, we are developing novel experimental methods to characterize the redox-properties of our thin films. These characterization methods can also be extended to probe the properties of biological materials.
Gregory Payne and William Bentley
In our research, we are developing novel experimental methods to characterize the redox-properties of our thin films. These characterization methods can also be extended to probe the properties of biological materials.
Melanin is a complex and poorly understood biological material that has been reported to have both beneficial (protective) and detrimental (pro-oxidant) properties. Interestingly, the brain neurons that are selectively vulnerable in Parkinson’s disease are rich in neuromelanin.
Paraquat is an agricultural chemical that has been linked to Parkinson’s disease through epidemiological evidence.
In this study, we demonstrate that paraquat undergoes redox-cycling interactions with melanin.
By applying novel characterization methods, it was possible to reveal previously-unknown interactions that may have important implications in disease etiology.