The convergence of new computational capabilities, advanced characterization techniques and the ability to generate and harness large-scale data enables new pathways for the discovery, development and deployment of advanced materials systems. This program engages an engineering and computer science team to develop a fundamental framework for design of new multilayered materials systems for energy efficient power generation and aircraft propulsion. Novel complementary computational and experimental tools will be developed and integrated with existing tools to accelerate development of a newly discovered cobalt-base substrate material along with compatible environmental protection layers. The program will take a systems approach, developing tools and models that permit simultaneous design of the layered system, going beyond the linear, experiment-driven approach historically employed for independent development of these critical system elements.