Presently, the field of metallurgy is undergoing a renaissance spurred on by the realization that useful structural alloys can be formed by mixing many different types of atoms in roughly equal proportions. These materials are referred to as “multi-principal-element” alloys (MPEAs), and this approach has already given rise to the discovery of new strong and ductile alloys. However, these examples have been based on only a small subset of the atoms in the periodic table, and only a limited number of underlying crystal structures. The initial discoveries are encouraging, but the true potential of MPEAs is yet to be tapped. In this Designing Materials to Revolutionize and Engineer our Future (DMREF) project, advanced materials theory and high-throughput computation and experiments are combined with the tools of machine learning to accelerate the discovery and development of a relatively unexplored class of MPEAs in which the atoms of the alloy are arranged in a hexagonal pattern. This research area is ripe for transformative discoveries for targeted applications including the focus of this project: stronger and lighter alloys for low temperature structural applications inspired by the conditions encountered in space exploration. The project emphasizes alloys that can be fabricated through additive manufacturing, commonly referred to as metal 3D printing. Hence the alloys will be available for immediate technological applications because additive manufacturing offers great opportunities for rapid fabrication of components with complex geometries and tailored structures at the microscopic scale. These research goals will be achieved by harnessing the power of materials data while educating the next generation of materials researchers, and accordingly, the project is well aligned with the goals of the Materials Genome Initiative.