In our materials-limited world, developing new materials is the foundation of technological progress. The current approach to materials design relies on trial-and-error exploration of chemicals and reactions to achieve a target function where structure–property relationships are identified only in retrospect is woefully inefficient. The proposed research will disrupt this status quo by developing a foundation for conceptually new processes, where discovered molecular codes will instruct the continuous flow synthesis of materials with encoded combinations of physical properties. Implementing digital codes in soft matter design will drive new synthetic pathways, stimulate new physical models, and catalyze fundamental shifts in various technologies, including personalized medicine, soft robotics, and sustainable materials fabrication. Collaboration with the Ackland Museum of Art will educate students on the connection between Materials Science concepts and Art in different cultures across human history. Building on this knowledge, participating students will create artwork merging Materials Science and Art. In addition, the DMREF team will develop the CREATE (Consider, Read, Elucidate the hypothesis, Analyze and interpret data, and Think of the next Experiment) method to give undergraduate students creative ownership of the research design and execution, as well as build an inclusive environment. This DMREF team also proposes to actively recruit and support women and underrepresented groups, including but not limited to people with disabilities and low-income students.