Advanced materials are introduced into engineering applications through an iterative development cycle including both materials characterization and computational models of materials processing and properties. This process is slowed, however, by the need for humans to be involved at almost every stage of the cycle. In this program we are creating  the Open Materials Semantic Infrastructure (OpenMSI) to enable an automated data flow in which each task in the loop automatically pushes information to, or pulls information from, a common data layer. This will accelerate materials design by minimizing the required human intervention, while still allowing human input to the loop where essential.