Generation, Functionalization and Distribution of de novo Designed Protein Nanomaterials
Proteins are large molecules that have complex three-dimensional (3D) structures that give them sophisticated cellular functions. To provide access to complex protein structures not found in nature, Professors Baker and King of the University of Washington and Professor Yeates of University of California Los Angeles collaborate to compute and precisely control the assembly of proteins into 3D architectures. The research team shares these capabilities with the engineering and scientific communities and constructs a Designed Protein Nanomaterial (DPN) database to enable others to rapidly build on these advances. The long-term goal is to allow predictable design of protein-based materials for use in a wide range of applications such as targeted drug delivery, functional materials for energy conversion, and other chemical technologies. The interdisciplinary project provides excellent research training opportunities to postdoctoral researchers and students.
Publications
Computational design of non-porous pH-responsive antibody nanoparticles
E. C. Yang, R. Divine, M. C. Miranda, A. J. Borst, W. Sheffler, J. Z. Zhang, J. Decarreau, A. Saragovi, M. Abedi, N. Goldbach, M. Ahlrichs, C. Dobbins, A. Hand, S. Cheng, M. Lamb, P. M. Levine, S. Chan, R. Skotheim, J. Fallas, G. Ueda, J. Lubner, M. Somiya, A. Khmelinskaia, N. P. King, and D. Baker
5/9/2024
Blueprinting extendable nanomaterials with standardized protein blocks
T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, C. Weidle, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, H. L. Han, K. D. Carr, Z. Li, R. McHugh, G. Reggiano, A. Kang, B. Sankaran, M. S. Dickinson, B. Coventry, T. J. Brunette, Y. Liu, J. Dauparas, A. J. Borst, D. Ekiert, J. M. Kollman, G. Bhabha, and D. Baker
3/13/2024
Macromolecular Cargo Encapsulation via In Vitro Assembly of Two‐Component Protein Nanoparticles
K. Herpoldt, C. L. López, I. Sappington, M. N. Pham, S. Srinivasan, J. Netland, K. S. Montgomery, D. Roy, A. N. Prossnitz, D. Ellis, A. J. Wargacki, M. Pepper, A. J. Convertine, P. S. Stayton, and N. P. King
2/11/2024
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Research Highlights
Blueprinting Extendable Nanomaterials with Standardized Protein Blocks
David Baker (U. Washington)
10/25/2024
Increasing Computational Protein Design Literacy through Cohort-based Learning for Undergraduate Students
David Baker and Neil King (U. Washington)
10/25/2024
Computational Design of Mechanically Coupled Axle-rotor Protein Assemblies
Neil King and David Baker (U. Washington)
10/25/2024